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Gabapentinoids and COPD exacerbations

https://doi.org/10.1136/dtb.2025.000010

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    Key learning points

    • Gabapentinoids are associated with respiratory depression and medicine regulators have issued safety warnings urging caution when prescribing to those with compromised respiratory function.

    • A Canadian cohort study found that gabapentin and pregabalin use was associated with an increased risk of severe exacerbations of chronic obstructive pulmonary disease .

    • The risk was comparable for all gabapentinoid indications including epilepsy, neuropathic pain and other chronic pain.

    A retrospective cohort study has provided further evidence of an association between the use of gabapentinoids and an increased risk of severe exacerbations of chronic obstructive pulmonary disease.1

    Overview

    This cohort study assessed whether gabapentinoid use was associated with severe exacerbations among patients aged >55 years with chronic obstructive pulmonary disease (COPD).1 It used a time-conditional propensity score-matched new-user design in which new users of gabapentinoids were …

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    Footnotes

    • Contributors DTB Team.

    • Provenance and peer review Commissioned; internally peer reviewed.