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Very small risk of stroke and MI associated with triptans

https://doi.org/10.1136/dtb.2024.000068

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    Key messages

    • Triptans are contraindicated for people with coronary artery or cerebrovascular disease.

    • A case-crossover study found that triptans were associated with a very small increased risk of myocardial infarction and stroke, occurring mainly in middle-aged patients with cardiovascular risk factors.

    • Absolute numbers of vascular events were low, with an estimated risk of 1 in 30000 new users.

    A self-controlled cross-over study found that starting a triptan was associated with a slight increased risk of myocardial infarction (MI) and stroke but for people who were at low cardiovascular risk, the risk of an ischaemic event was very small.1

    Overview

    The study used data from Danish nationwide health registers to evaluate the association between triptan use and three outcomes: MI, ischaemic stroke and ischaemic or unspecified stroke.1 The authors included patients aged 18 years or older who …

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    Footnotes

    • Contributors DTB Team.

    • Provenance and peer review Commissioned; internally peer reviewed.